HCID 58872449, compound → HCID 58872505, compound

HRID 645008Notes

Reaction equation

HRID 645008 reaction equation
BrC1C=CC=C2C=1C(C1C(O)=CC3OCOC=3C=1)[C:5](=[O:16])N2CCCCC.[CH2:27]([O:34][CH2:35][CH2:36][CH2:37][N:38]1[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:40]([C:47]2[C:55]([OH:56])=[CH:54][C:50]3[O:51][CH2:52][O:53][C:49]=3[CH:48]=2)[C:39]1=[O:57])[C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[CH2:27]([O:34][CH2:35][CH2:36][CH2:37][N:38]1[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[C:40]([C:47]2[C:55]([OH:56])=[CH:54][C:50]3[O:51][CH2:52][O:53][C:49]=3[CH:48]=2)([CH2:5][OH:16])[C:39]1=[O:57])[C:28]1[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

3

Reactant 2

HCID 58872449HCID 58872449, compoundHCID 588725004-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one

Product 1

HCID 58872505HCID 58872505, compound

Procedure

Following the procedure as described in PREPARATION 1E, and making non-critical variations to replace 4-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1-pentyl-1,3-dihydro-2H-indol-2-one with 1-[3-(benzyloxy)propyl]-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one, the title compound was obtained (93%): MS (ES+) m/z 448.2 (M+1).

Sources & evidence

ORD record
ord-7aaab1bc3a4f4701b77237662da6f09d
Source dataset
uspto-grants-2010_04
Patent number
US07700641B2

Reaction notes

Loading…