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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645192Generated: October 28, 2026

Ethyl(4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'h)-yl)acetate → (4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'H)-yl)acetic acid

https://huagongshe.com/reaction/645192

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl(4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'h)-yl)acetateHCID 59263373—
Reactantethyl(2'-oxospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-1'(2'H)-yl)acetateHCID 59263415—
Product(4'-bromo-5,6-difluoro-2'-oxospiro[1-benzofuran-3,3'-indol]-1'(2'H)-yl)acetic acidHCID 66641960100%

Reaction Steps

Following the procedure as described in EXAMPLE 2, and making non-critical variations using ethyl(4′-bromo-5,6-difluoro-2′-oxospiro[1-benzofuran-3,3′-indol]-1′(2′ H)-yl)acetate to replace ethyl(2′-oxospiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-1′(2′H)-yl)acetate, the title compound was obtained in 100% yield. The product was used directly in the next step.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07700641B2
Source datasetuspto-grants-2010_04
ORD IDord-be6691ee7bd24ee4a1fc0c3da03f8d54
Source noteuspto-grants-2010_04