1-(Bromomethyl)-4-(trifluoromethoxy)benzene → 1'[4-(trifluoromethoxy)benzyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Participants

Role	Name	HCID	Charge
Reactant	1-(Bromomethyl)-4-(trifluoromethoxy)benzene	HCID 142785	—
Reactant	2-(Bromomethyl)-5-(trifluoromethyl)furan	HCID 2794605	—
Reactant	spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one	HCID 53375495	—
Reactant	5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1H)-one	HCID 59263470	—
Product	1'[4-(trifluoromethoxy)benzyl]spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one	HCID 59263401	—

Reaction Steps

Following the procedure described in EXAMPLE 10.21, and making non-critical variations using spiro[furo[2,3-f][1,3]benzodioxole-7,3′-indol]-2′(1′H)-one to replace 5,5-dimethyl-5,6-dihydrospiro[benzo[1,2-b:5,4-b′]difuran-3,3′-indol]-2′(1′H)-one, and 1-(bromomethyl)-4-(trifluoromethoxy)benzene to replace 2-(bromomethyl)-5-(trifluoromethyl)furan, the title compound was obtained (50%) as a white solid: mp 99-101° C.; MS (ES+) m/z 456.3 (M+1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07700641B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-a3fd7f050d624172b64460d171531512
Source note	uspto-grants-2010_04