N,N-Dimethyl-1,3-propanediamine → gamma-benzyl-L-glutamic acid Nepsilon-benzyloxycarbonyl-L-lysine

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Reaction Conditions

Reaction Steps

To 1,2-dichloroethane (10 ml) was added N-carboxy-γ-benzyl-L-glutamic acid anhydride (1.00 g, 3.80 mmol), and the mixture was cooled to 0° C. N,N-Dimethyl-1,3-propanediamine (9.56 μl, 0.076 mmol) was added as an initiator, and the mixture was stirred at 25° C. for 1 day and cooled again to 0° C. Nα-Carboxy-Nε-benzyloxycarbonyl-L-lysine anhydride (1.16 g, 3.80 mmol) was added, and the mixture was stirred at 25° C. for 1 day to give a γ-benzyl-L-glutamic acid-Nε-benzyloxycarbonyl-L-lysine block copolymer (low molecular weight copolymer). The weight average molecular weight, Mw, of the copolymer was measured by Measurement Method 1 described below. In addition, the composition of the copolymer was measured by Measurement Method 2 described below.

Provenance & Evidence