epsilon-(Benzyloxycarbonyl)-L-lysine → gamma-benzyl-L-glutamic acid Nepsilon-benzyloxycarbonyl-L-lysine

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Reaction Steps

The synthesized copolymer (10 mg) was dissolved in deuterated trifluoroacetic acid, and the 1H NMR was measured. As a result, a peak derived from the benzyl group of Nε-benzyloxycarbonyl-L-lysine and the benzyl group of γ-benzyl-L-glutamic acid was detected near 5.1 ppm, a peak derived from the proton at the α-position of γ-benzyl-L-glutamic acid was detected near 4.7 ppm, and a peak derived from the proton at the α-position of Nε-benzyloxycarbonyl-L-lysine was detected near 4.4 ppm. When the peak areas near 5.1 ppm, 4.7 ppm, 4.4 ppm are A, B, C, respectively, A/B=4.00, A/C=4.00, and B/C=1.00. Since both B and C represent an area of one proton, the composition of the copolymer is γ-benzyl-L-glutamic acid (50%)/Nε-benzyloxycarbonyl-L-lysine (50%).

Provenance & Evidence