HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Benzyl-8-methyl-3,8-diazabicyclo[3.2.1]octane → 8-Methyl-3,8-diazabicyclo[3.2.1]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Benzyl-8-methyl-3,8-diazabicyclo[3.2.1]octane | HCID 422671 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 8-Methyl-3,8-diazabicyclo[3.2.1]octane | HCID 422924 | — |
Reaction Steps
To a degassed by argon solution of 3-benzyl-8-methyl-3,8-diazabicyclo[3.2.1]octane (17.6 g, 0.08 mol) in methanol (50 ml), 10% Pd/C (1.0 g) was added and hydrogen passed into reaction mixture for 24 h. The catalyst was filtered off, the filtrate evaporated and the residue distilled on Büchi oven for distillation at 100° C. and 0.1 mbar. Yield 8.5 g (85%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07704991B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-33a76434fc514e28999509269bd069c3 |
| Source note | uspto-grants-2010_04 |