HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate → 8-Boc-3,8-diaza-bicyclo(3.2.1)octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tert-butyl 3-benzyl-3,8-diazabicyclo[3.2.1]octane-8-carboxylate | HCID 15740907 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 8-Boc-3,8-diaza-bicyclo(3.2.1)octane | HCID 15740908 | — |
Reaction Steps
A mixture of 3-benzyl-3,8-diaza-bicyclo[3.2.1]octane-8-carboxylic acid tert-butyl ester (13.0 g, 43.0 mmol), palladium on carbon (4.0 g, 5%) and ethanol (100 ml, 99%) was stirred under hydrogen. The mixture was filtered on celite, dried and evaporated. A white powder was isolated. Yield 8.4 g (92%). Mp 103.4-106° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07704991B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-22b8c09f52dd4a4584e4577c0b55a3a0 |
| Source note | uspto-grants-2010_04 |