Ethyl isocyanate → HCID 178465350, compound

HRID 645465Notes

Reaction equation

HRID 645465 reaction equation
[CH2:1]1[C:9]2[C:4](=[C:5]([N:10]3[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:23][CH2:22][C@H:21]([NH2:24])[CH2:20][CH2:19]4)[CH2:12][CH2:11]3)[CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1.[CH2:25]([N:27]=[C:28]=[O:29])[CH3:26]>ClCCl>[CH2:1]1[C:9]2[C:4](=[C:5]([N:10]3[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][C@H:18]4[CH2:19][CH2:20][C@H:21]([NH:24][C:28]([NH:27][CH2:25][CH3:26])=[O:29])[CH2:22][CH2:23]4)[CH2:14][CH2:15]3)[CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8022Ethyl isocyanateHCID 178511522HCID 178511522, compound

Product 1

HCID 178465350HCID 178465350, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

0.4 g (1 mmol) trans-4-{2-[4-(indan-4-yl)-piperazin-1-yl]-ethyl}-cyclohexyl-amine was dissolved in dry dichloromethane (30 ml), ethylisocyanate (0.1 ml, 1.3 mmol) was added and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed in vacuo. The residue was recrystallized from acetonitrile giving the title compound (0.22 g, 55%), melting at 198-200° C.

Workup

  1. customThe solvent was removed in vacuo
  2. customThe residue was recrystallized from acetonitrile giving the title compound (0.22 g, 55%), melting at 198-200° C.

Sources & evidence

ORD record
ord-94c29eb23a5541918b27f179f84bad7a
Source dataset
uspto-grants-2010_04
Patent number
US07705003B2

Reaction notes

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