Trifluoroacetic acid → HCID 68708606, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-(2-{5-benzylcarbamoyl-2-cyano-6-[(spiro[2.5]oct-6-ylmethyl)amino]-pyrimidin-4-yloxy}ethyl)piperidine-1-carboxylic acid tert-butyl ester (0.68 mmol) in CH2Cl2 (10 mL) is added TFA (2 mL) at 0° C. After stirring for 2 h at 0° C. under N2 atmosphere, the mixture is concentrated and dried in vacuo to give 2-cyano-4-(2-piperidin-4-yl-ethoxy)-6-[(spiro[2.5]oct-6-ylmethyl)amino]pyrimidine-5-carboxylic acid benzyl amide as a yellow solid. 1H-NMR (CDCl3), δ 0.17-0.30 (4H, m), 0.89-0.93 (2H, m), 1.00-1.11 (2H, m), 1.14-1.24 (2H, m), 1.29-1.38 (1H, m), 1.51-1.81 (9H, m), 2.41-2.48 (2H, m), 2.99-3.02 (2H, m), 3.42 (2H, t), 4.45 (2H, t), 4.56 (2H, d), 7.29-7.39 (5H, m), 8.17 (1H, t), 10.16 (1H, t).

Provenance & Evidence