1-Methyl-3-pyrrolidinol → HCID 86082305, compound

HRID 645535Notes

Reaction equation

HRID 645535 reaction equation
[C:1]([C:3]1[C:4](Cl)=[N:5][C:6]([Cl:10])=[C:7]([F:9])[CH:8]=1)#[N:2].[CH3:12][N:13]1[CH2:17][CH2:16][CH:15]([OH:18])[CH2:14]1>>[Cl:10][C:6]1[C:7]([F:9])=[CH:8][C:3]([C:1]#[N:2])=[C:4]([O:18][CH:15]2[CH2:16][CH2:17][N:13]([CH3:12])[CH2:14]2)[N:5]=1

Participants

3

Reactant 2

HCID 930741-Methyl-3-pyrrolidinolHCID 27338492,6-Dichloro-5-fluoro-3-pyridinecarbonitrile

Product 1

HCID 86082305HCID 86082305, compound

Procedure

3-cyano-2,6-dichloro-5-fluoropyridine was reacted with 1-methyl-pyrrolidin-3-ol according to the method of Example 85A to provide the title compound. MS (ESI+) m/z 256 (M+H)+.

Sources & evidence

ORD record
ord-17010bddcf27491a8f6b224e672a2610
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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