Benzyl mercaptan → 2-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene

Participants

Role	Name	HCID	Charge
Reactant	Benzyl mercaptan	HCID 7509	—
Reactant	Sodium hydride	HCID 24758	—
Reactant	Benzene, 2-chloro-1-(3,4-dinitrophenoxy)-4-(trifluoromethyl)-	HCID 156238	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	2-Benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene	HCID 20236281	—

Reaction Steps

1.7 g of benzyl mercaptan was dissolved in dry tetrahydrofuran and 0.5 g of sodium hydride added with stirring under dry nitrogen. The reaction mixture was stirred under reflux for 30 minutes, and a solution of 5 g of 1A dissolved in 25 ml of dry tetrahydrofuran was added dropwise. Reaction occurred rapidly, and the product was chromatographically purified to give 2-benzylthio-4-(2-chloro-4-trifluoromethylphenoxy)nitrobenzene (1B) as a yellow oil.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04609394
Source dataset	uspto-grants-1986_09
ORD ID	ord-a90262bdbc264b34851ba14fae0a069f
Source note	uspto-grants-1986_09