Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiophosgene → 2-Fluoro-1-isothiocyanato-3-trifluoromethyl-benzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiophosgene | HCID 10040 | — |
| 반응물 | 3-Amino-2-fluorobenzotrifluoride | HCID 145569 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-Fluoro-1-isothiocyanato-3-trifluoromethyl-benzene | HCID 83402407 | 91% |
반응 단계
To a two phase solution of 2-fluoro-3-trifluoromethyl-phenylamine (2 g, 11.17 mmole) in dichloromethane (40 ml) and sodium bicarbonate (6.57 g, 78.19 mmole) in water (30 ml) at 0° C. was added dropwise a solution of thiophosgene (1.28 g, 11.17 mmole) in dichloromethane (10 ml). After 2 hrs, the organic layer was separated, washed sequentially with 1M NaHCO3, brine and water. The organic layer was dried over Na2SO4, filtered and concentrated to yield 2.2 g (91%) of product as a viscous liquid. MS (ESI+) m/z 221 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07704997B1 |
| 출처 데이터셋 | uspto-grants-2010_04 |
| ORD ID | ord-cf0ee22f5cc94cfc926380c79a751eaf |
| 출처 메모 | uspto-grants-2010_04 |