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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645595Generated: October 29, 2026

4,5-Difluoro-2-(pyridin-2-yloxy)benzonitrile → 1-[4,5-Difluoro-2-(pyridin-2-yloxy)phenyl]methanamine

https://huagongshe.com/reaction/645595

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,5-Difluoro-2-(pyridin-2-yloxy)benzonitrileHCID 68583361—
CatalystNickelHCID 935—
Product1-[4,5-Difluoro-2-(pyridin-2-yloxy)phenyl]methanamineHCID 68582586—

Reaction Steps

The product of Example 136B and Raney/nickel were processed according to the method of Example 131C to provide the product. MS (ESI+) m/z 237 (M+H)+;

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07704997B1
Source datasetuspto-grants-2010_04
ORD IDord-ec2f678075e142dd997b2436aed13347
Source noteuspto-grants-2010_04