Methanol → 4-Chloro-6-methoxy-1,3,5-triazin-2-amine

Participants

Reaction Steps

To a suspension of 50.0 g (0.3 mol) of 2-amino-4,6-dichloro-1,3,5-triazine in 600 mL of methanol was added portionwise 19.5 g (0.3 mol) of 85% potassium hydroxide pellets with the temperature being kept between 15°-20°. The resulting suspension was stirred at 10°-15° for one hour and then allowed to warm to room temperature over 1.5 hours. The white solid was collected, washed three times with water, and dried in vacuo to give 37.1 g of 2-amino-4-chloro-6-methoxy-1,3,5-triazine with m.p. 221°-223.5° (dec).

Provenance & Evidence