2,3-Dichlorophenyl Isothiocyanate → HCID 86082285, compound

HRID 645602Notes

Reaction equation

HRID 645602 reaction equation
Cl.[Br:2][C:3]1[C:8]([CH2:9][NH2:10])=[CH:7][CH:6]=[CH:5][N:4]=1.[Cl:11][C:12]1[C:17]([Cl:18])=[CH:16][CH:15]=[CH:14][C:13]=1[N:19]=[C:20]=[S:21]>>[Br:2][C:3]1[C:8]([CH2:9][NH:10][C:20]([NH:19][C:13]2[CH:14]=[CH:15][CH:16]=[C:17]([Cl:18])[C:12]=2[Cl:11])=[S:21])=[CH:7][CH:6]=[CH:5][N:4]=1

Participants

3

Reactant 2

HCID 27962812,3-Dichlorophenyl IsothiocyanateHCID 86082284HCID 86082284, compound

Product 1

HCID 86082285HCID 86082285, compoundYield 55%

Procedure

Prepared in 55% yield by treatment of the product of Example 142A with 2,3-dichlorophenylisothiocyanate according to the procedure described for Example 141B. MS (ESI−) m/z 389.9 (M+H)+; 1H NMR (DMSO-d6) δ 4.71 (d, J=4.4 Hz, 2H), 7.37 (dd, J=8.0, 8.0 Hz, 1H), 7.48 (dd, J=7.5, 4.7 Hz, 1H), 7.55 (dd, J=8.1, 1.7 Hz, 1H), 7.58-7.63 (m, 1H), 7.69 (dd, J=7.6, 1.9 Hz, 1H), 8.29 (dd, J=4.7, 2.0 Hz, 1H), 8.44 (br s, 1H), 9.70 (br s, 1H).

Sources & evidence

ORD record
ord-00a6788024ee48fba8489ee975e0805f
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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