2-Chloronicotinonitrile → HCID 68583656, compound

HRID 645614Notes

Reaction equation

HRID 645614 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[F:10][C:11]([F:23])([F:22])[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=1B(O)O>>[F:10][C:11]([F:22])([F:23])[O:12][C:13]1[CH:18]=[CH:17][C:16]([C:2]2[N:3]=[CH:4][CH:5]=[CH:6][C:7]=2[C:8]#[N:9])=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)

Product 1

HCID 68583656HCID 68583656, compoundYield 71%

Procedure

Prepared in 71% yield from 2-chloro-3-cyanopyridine and 2-trifluoromethoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 264.8 (M+H)+; 1H NMR (CDCl3) δ 7.41-7.48 (m, 3H), 7.54-7.60 (m, 2H), 8.09 (dd, J=7.8, 1.7 Hz, 1H), 8.91 (dd, J=5.1, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-296a641a07634d2aa8f1585810cc31e6
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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