2-Chloronicotinonitrile → HCID 68584576, compound

HRID 645617Notes

Reaction equation

HRID 645617 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[F:10][C:11]([F:22])([F:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1B(O)O>>[F:10][C:11]([F:22])([F:21])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[C:2]1[N:3]=[CH:4][CH:5]=[CH:6][C:7]=1[C:8]#[N:9]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 27343872-(Trifluoromethyl)benzeneboronic acid

Product 1

HCID 68584576HCID 68584576, compoundYield 30%

Procedure

Prepared in 30% yield from 2-chloro-3-cyanopyridine and 2-trifluoromethylphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 249.0 (M+H)+; 1H NMR (CDCl3) δ 7.45-7.50 (m, 2H), 7.62-7.72 (m, 2H), 7.83-7.86 (m, 1H), 8.09 (dd, J=7.8, 1.7 Hz, 1H), 8.87 (dd, J=5.7, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-a4147c4af1ef410f952deb9e18ccd55b
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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