1,3,5-Triazin-2-amine, 4-methoxy-6-(2,2,2-trifluoroethoxy)- → N-[[4-methoxy-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]aminocarbonyl]-2-propoxybenzenesulfonamide

HRID 64562Notes

Reaction equation

HRID 64562 reaction equation
[NH2:1][C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]([F:13])([F:12])[F:11])[N:5]=[C:4]([O:14][CH3:15])[N:3]=1.[CH2:16]([O:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[S:26]([N:29]=[C:30]=[O:31])(=[O:28])=[O:27])[CH2:17][CH3:18]>C(Cl)Cl>[CH3:15][O:14][C:4]1[N:5]=[C:6]([O:8][CH2:9][C:10]([F:11])([F:13])[F:12])[N:7]=[C:2]([NH:1][C:30]([NH:29][S:26]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=2[O:19][CH2:16][CH2:17][CH3:18])(=[O:28])=[O:27])=[O:31])[N:3]=1

Participants

4

Reactant 2

HCID 1809581,3,5-Triazin-2-amine, 4-methoxy-6-(2,2,2-trifluoroethoxy)-HCID 137267662-Propoxybenzene-1-sulfonyl isocyanate

Product 1

HCID 13726767N-[[4-methoxy-6-(2,2,2-trifluoroethoxy)-1,3,5-triazin-2-yl]aminocarbonyl]-2-propoxybenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To 2.0 g of 2-amino-4-(2,2,2-trifluoroethoxy)-6-methoxy-1,3,5-triazine suspended in 35 mL of dry methylene chloride was added 4.4 g of a 50% solution of 2-n-propoxybenzenesulfonyl isocyanate in methylene chloride. The mixture was stirred overnight at ambient temperature and the resulting solution stripped to an amber oil which was triturated with ethanol to give 1.42 g of white solid with m.p. 161°-163° (dec).

Workup

  1. customwas triturated with ethanol

Sources & evidence

ORD record
ord-ef24c1c7ef6a420bb1a8c2687b81af4a
Source dataset
uspto-grants-1986_09
Patent number
US04609398

Reaction notes

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