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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645624Generated: November 1, 2026

4-Fluorophenylboronic acid → 5-Fluoro-2-(4-fluorophenyl)nicotinonitrile

https://huagongshe.com/reaction/645624

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Fluorophenylboronic acidHCID 285645—
Reactant2-Chloro-5-fluoropyridine-3-carbonitrileHCID 23110851—
Product5-Fluoro-2-(4-fluorophenyl)nicotinonitrileHCID 6858326968%

Reaction Steps

Prepared in 68% yield from the product of Example 169A and 4-fluorophenylboronic acid according to the procedure described for Example 153A. 1H NMR (DMSO-d6) δ 7.39-7.45 (m, 2H), 7.87-7.92 (m, 2H), 8.58 (dd, J=8.6, 2.9 Hz, 1H), 8.99 (d, J=3.0 Hz, 1H).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07704997B1
Source datasetuspto-grants-2010_04
ORD IDord-ac9cffa5b3144cff87adc0dafe1794a5
Source noteuspto-grants-2010_04