2-Chloronicotinonitrile → HCID 68582183, compound

HRID 645626Notes

Reaction equation

HRID 645626 reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:10][C:11]1[CH:12]=[CH:13][C:14]([O:20][CH3:21])=[C:15](B(O)O)[CH:16]=1>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([O:20][CH3:21])=[C:13]([C:2]2[N:9]=[CH:8][CH:7]=[CH:6][C:3]=2[C:4]#[N:5])[CH:12]=1

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 27826735-Fluoro-2-methoxyphenylboronic acid

Product 1

HCID 68582183HCID 68582183, compoundYield 89%

Procedure

Prepared in 89% yield from 2-chloronicotinonitrile and 5-fluoro-2-methoxyphenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 228.9 (M+H)+; 1H NMR (CDCl3) δ 3.86 (s, 3H), 6.98 (dd, J=8.8, 4.0 Hz, 1H), 7.13-7.22 (m, 2H), 7.40 (dd, J=8.0, 4.9 Hz, 1H), 8.04 (dd, J=8.1, 1.7 Hz, 1H), 8.88 (dd, J=5.1, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-6001df55d9884bca8b1f12b55ed912ed
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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