2-Chloronicotinonitrile → HCID 68584169, compound

HRID 645630Notes

Reaction equation

HRID 645630 reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:10][C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1B(O)O>>[F:10][C:11]1[C:16]([F:17])=[CH:15][CH:14]=[CH:13][C:12]=1[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 2734333(2,3-Difluorophenyl)boronic acid

Product 1

HCID 68584169HCID 68584169, compoundYield 91%

Procedure

Prepared in 91% yield from 2-chloronicotinonitrile and 2,3-difluorophenylboronic acid according to the procedure described for Example 153A. MS (ESI−) m/z 216.9 (M+H)+; 1H NMR (CDCl3) δ 7.21-7.29 (m, 1H), 7.30-7.39 (m, 2H), 7.49 (dd, J=8.0, 4.9 Hz, 1H), 8.12 (dd, J=7.8, 1.7 Hz, 1H), 8.92 (dd, J=4.9, 1.9 Hz, 1H).

Sources & evidence

ORD record
ord-299da87aafbe44f98fabdf0f2c882609
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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