2-Chloronicotinonitrile → HCID 68582671, compound

HRID 645631Notes

Reaction equation

HRID 645631 reaction equation
Cl[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[F:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1B(O)O>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[C:2]1[N:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5]

Participants

3

Reactant 2

HCID 810792-ChloronicotinonitrileHCID 2734335(2,5-Difluorophenyl)boronic acid

Product 1

HCID 68582671HCID 68582671, compoundYield 66%

Procedure

Prepared in 66% yield from 2-chloronicotinonitrile and 2,5-difluorophenylboronic acid according to the procedure described for Example 153A. 1H NMR (CDCl3) δ 7.19-7.23 (m, 2H), 7.29-7.34 (m, 1H), 7.48 (dd, J=8.0, 4.9 Hz, 1H), 8.10 (dd, J=8.0, 1.9 Hz, 1H), 8.92 (dd, J=5.1, 1.7 Hz, 1H).

Sources & evidence

ORD record
ord-247fbbef09c4430aa567d38b6eaa4dbc
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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