3-Cyano-2-fluoropyridine → HCID 68582028, compound

HRID 645634Notes

Reaction equation

HRID 645634 reaction equation
[C:1]([C:3]1[C:4](F)=[N:5][CH:6]=[CH:7][CH:8]=1)#[N:2].Cl.[NH:11]1[CH2:14][CH2:13][CH2:12]1>>[N:11]1([C:4]2[N:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:1]#[N:2])[CH2:14][CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 27832543-Cyano-2-fluoropyridineHCID 12308726Azetidine hydrochloride

Product 1

HCID 68582028HCID 68582028, compoundYield 82%

Procedure

Prepared in 82% yield from 3-cyano-2-fluoropyridine and azetidine hydrochloride according to the procedure described for Example 178A. MS (ESI+) m/z 160.0 (M+H)+; 1H NMR (DMSO-d6) δ 2.28-2.38 (m, 2H), 4.19-4.25 (m, 4H), 6.73 (Dd, J=7.6, 4.9 HZ, 1H), 7.92 (dd, J=7.7, 1.8 Hz, 1H), 8.30 (dd, J=4.9, 1.9 Hz, 1H).

Sources & evidence

ORD record
ord-a26a50633faf43449ffff735243ce562
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

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