2-Phenylpyrrolidine → HCID 68582652, compound

HRID 645652Notes

Reaction equation

HRID 645652 reaction equation
Cl[C:2]1[N:6]([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([Cl:13])[C:8]=2[Cl:14])[N:5]=[N:4][N:3]=1.[C:15]1([CH:21]2[CH2:25][CH2:24][CH2:23][NH:22]2)[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[Cl:14][C:8]1[C:9]([Cl:13])=[CH:10][CH:11]=[CH:12][C:7]=1[N:6]1[C:2]([N:22]2[CH2:23][CH2:24][CH2:25][CH:21]2[C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:3][N:4]=[N:5]1

Participants

3

Reactant 2

HCID 2618922-PhenylpyrrolidineHCID 59689467HCID 59689467, compound

Product 1

HCID 68582652HCID 68582652, compoundYield 20.1%

Procedure

The product of Example 75B (0.1 g) was reacted with 2-phenylpyrrolidine (0.1 g) according to the method of Example 75C to provide 0.029 g of the title compound as a white solid. MS (ESI/NH3) m/z 359 (M+H)+. 1H NMR (DMSO-d6) δ 1.78-1.9 (m, 4H), 3.3-3.6 (m, 2H), 4.8-5.0 (m, 1H) 6.8-6.9 (m, 1H), 7.0-7.2 (m, 5H), 7.59-7.65 (t, 1H), 7.79-7.85 (d, 1H), 7.95-7.99 (d, 1H).

Sources & evidence

ORD record
ord-5bb4c7986ef7453184a3bc4040e64ffb
Source dataset
uspto-grants-2010_04
Patent number
US07704997B1

Reaction notes

Loading…