HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645688Generated: October 25, 2026
Sulfanilamide → 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide
https://huagongshe.com/reaction/645688
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sulfanilamide | HCID 5333 | — |
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86628035 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide | HCID 68579482 | 56.3% |
Reaction Steps
A mixture of 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (150 mg, 0.34 mmol), sulfanilamide (125 mg, 0.73 mmol) and trimethylsilyl chloride (TMSCl) (0.100 mL, 0.79 mmol) inn-butyl alcohol (4 mL) was heated at 116° C. for 96 h. The mixture was then purified by HPLC to give 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzenesulfonamide (110 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07705004B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-f6a5d8a5e86a40c593b6ebf333a30396 |
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| Source note | uspto-grants-2010_04 |
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