HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 645690Generated: October 26, 2026
Chlorotrimethylsilane → 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide
https://huagongshe.com/reaction/645690
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chlorotrimethylsilane | HCID 6397 | — |
| Reactant | 4-Aminobenzamide | HCID 76079 | — |
| Reactant | 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine | HCID 86628035 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide | HCID 68579268 | 27.3% |
Reaction Steps
A mixture of 2-chloro-N-(1H-indazol-6-yl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (150 mg, 0.34 mmol), 4-aminobenzamide (93 mg, 0.68 mmol) and trimethylsilyl chloride (TMSCl) (0.100 mL, 0.79 mmol) inn-butyl alcohol (4 mL) was heated at 116° C. for 96 h. The mixture was then purified by HPLC to give 4-(4-(1H-indazol-6-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide (50 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07705004B2 |
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| Source dataset | uspto-grants-2010_04 |
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| ORD ID | ord-b49d6fba20584021ad3069c7253af899 |
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| Source note | uspto-grants-2010_04 |
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