Potassium Hydroxide → HCID 25196009, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N4-(1H-indazol-6-yl)-N2-(4-(4-methylpiperazin-1-yl)phenyl)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (29 mg, 0.049 mmol) in methanol (MeOH) (2 mL), aq. 1N KOH (1.0 mL, 1.0 mmol) was added. The mixture was then heated at 60° C. for 4 h. before it was concentrated in vacuo. The residue was then acidified with acetic acid (HOAc) (2.0 mL) and purified by HPLC to give the title compound (10 mg). MS 440.2 (M+H) (Compound 13-1).

Provenance & Evidence