Acetic Acid → 4-(4-(1-methyl-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide

Participants

Role	Name	HCID	Charge
Reactant	Acetic Acid	HCID 176	—
Reactant	Potassium Hydroxide	HCID 14797	—
Reactant	4-(4-(1-methyl-1H-indazol-5-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide	HCID 68581628	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	4-(4-(1-methyl-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide	HCID 25196228	24.4%

Reaction Conditions

Temperature	70 °C

Reaction Steps

To a solution of 4-(4-(1-methyl-1H-indazol-5-ylamino)-7-tosyl-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)benzamide (40 mg, 0.072 mmol) in dioxane (2 mL), aq. 1N KOH (1.8 mL, 1.80 mmol) was added. The mixture was stirred at 70° C. for 20 h. HOAc (1.0 mL) was added. The mixture was purified by HPLC to give the titled compound (7 mg). MS 399.2 (M+H) (Compound 25-1).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705004B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-d03daef91127444fb8c40f5ff1a4006b
Source note	uspto-grants-2010_04