4-Nitroindazole → NoName_3327

HRID 645717Notes

Reaction equation

HRID 645717 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][NH:8]2)([O-])=O>CCO.[Pd]>[NH2:1][C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH:6]=[N:7][NH:8]2

Participants

4

Reactant 1

HCID 180574-Nitroindazole

Product 1

HCID 413085NoName_3327Yield 102%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

In a second step, to a suspension of 4-nitroindazole (3 g, 18.4 mmol) in EtOH (75 ml) was added Pd on carbon (10%, 1.5 g), the mixture was charged with H2 at 50 psi for 1 h, Pd on carbon was filtered off, and the filtrate was concentrated to give 4-aminoindazole (2.5 g).

Workup

  1. additionthe mixture was charged with H2 at 50 psi for 1 h
  2. filtrationPd on carbon was filtered off
  3. concentrationthe filtrate was concentrated

Sources & evidence

ORD record
ord-bb3059f4a1224490998fa5acb73ddecf
Source dataset
uspto-grants-2010_04
Patent number
US07705004B2

Reaction notes

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