1-(2-Methanesulfonylethyl)piperazine dihydrochloride → cis-[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
Reactant	4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613622	—
Product	cis-[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone	HCID 24774798	—

Reaction Steps

4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 1) was reacted with 1-(2-methanesulfonylethyl)piperazine dihydrochloride to give cis-[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C30H34N5O4SCl2 [(M+H)+] 630.1703, observed 603.1705.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705007B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-7def2ca2311f4b8d9edc6121c083234b
Source note	uspto-grants-2010_04