N,N-dimethyl-2-(piperazin-1-yl)acetamide → cis-2-{4-[4,5-Bis-(4-chloro-phenyl)-2-(4-ethoxy-2-methyl-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-n,n-dimethyl-acetamide

Participants

Role	Name	HCID	Charge
Reactant	N,N-dimethyl-2-(piperazin-1-yl)acetamide	HCID 2758642	—
Reactant	4,5-Bis-(4-chloro-phenyl)-2-(4-ethoxy-2-methyl-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613630	—
Solvent	Dimethylacetamide	HCID 31374	—
Product	cis-2-{4-[4,5-Bis-(4-chloro-phenyl)-2-(4-ethoxy-2-methyl-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-n,n-dimethyl-acetamide	HCID 24775146	—

Reaction Steps

cis-4-[4,5-Bis-(4-chloro-phenyl)-2-(4-ethoxy-2-methyl-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 16) was reacted with N,N-dimethyl-2-piperazin-1-yl-acetamide (Oakwood Products) to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(4-ethoxy-2-methyl-pyrimidin-5-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N,N-dimethyl-acetamide in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C31H36N7O3Cl2 [(M+H)+] 624.2251, observed 624.2253.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705007B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-5d4cec265f4b4203867de7f4384a425a
Source note	uspto-grants-2010_04