1-(2-Methanesulfonylethyl)piperazine dihydrochloride → cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
Reactant	2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613632	—
Product	cis-[2-(2-Tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride	HCID 68580336	—

Reaction Steps

cis-4-[2-(2-tert-Butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 20) was reacted with 1-(2-methanesulfonyl-ethyl)piperazine dihydrochloride (example 3) to give cis-[2-(2-tert-butyl-4-ethoxy-pyrimidin-5-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone hydrochloride in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C33H41N6O4SCl2 [(M+H)+] 687.2282, observed 687.2286.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705007B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-f443f601a6104e08bf6ae0643536278d
Source note	uspto-grants-2010_04