HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | 3-(Methylsulfonyl)propyl methanesulfonate | HCID 10262758 | — |
| Reactant | N-(2-methoxy-1-methylethyl)-2-piperazin-1-yl-acetamide dihydrochloride | HCID 67245894 | — |
| Product | 1-(3-(Methylsulfonyl)propyl)piperazine dihydrochloride | HCID 49853479 | — |
Reaction Steps
1-(3-Methanesulfonyl-propyl)-piperazine dihydrochloride was prepared from 1-tert-butyloxycarbonyl-piperazine and methanesulfonic acid 3-methanesulfonyl-propyl ester (prepared according to Baerlocher, F. J. et al. Aust. J. Chem. 1999, 52, 167-172) in an analogous manner as described for the preparation of N-(2-methoxy-1-methyl-ethyl)-2-piperazin-1-yl-acetamide dihydrochloride (example 40).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705007B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-2d00d5a416a84e138dbe3dd3a13d688f |
| Source note | uspto-grants-2010_04 |