Phosgene → HCID 86613634, compound

HRID 645757Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[NH:11][C:10]([C:20]3[CH:21]=[N:22][C:23]([O:29][CH2:30][CH3:31])=[CH:24][C:25]=3[O:26][CH2:27][CH3:28])=[N:9]2)=[CH:4][CH:3]=1.[C:32](Cl)([Cl:34])=[O:33]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]2[CH:12]([C:13]3[CH:14]=[CH:15][C:16]([Cl:19])=[CH:17][CH:18]=3)[N:11]([C:32]([Cl:34])=[O:33])[C:10]([C:20]3[CH:21]=[N:22][C:23]([O:29][CH2:30][CH3:31])=[CH:24][C:25]=3[O:26][CH2:27][CH3:28])=[N:9]2)=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 6371Phosgene

HCID 86613635HCID 86613635, compound

Product 1

HCID 86613634HCID 86613634, compound

Procedure

Using the procedure as described in example 1, cis-4-[4,5-bis-(4-chloro-phenyl)-2-(4,6-diethoxy-pyridin-3-yl)-4,5-dihydro-1H-imidazole was reacted with phosgene to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(4,6-diethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride. The carbonyl chloride was then coupled with 2-piperazinone (Alfa) to give cis-4-[4,5-bis-(4-chloro-phenyl)-2-(4,6-diethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one hydrochloride.

Sources & evidence

ORD record: ord-138917a1ca174008aca77c9cd07e21af
Source dataset: uspto-grants-2010_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07705007B2

Reaction notes

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