1-(2-Hydroxyethyl)piperazine → HCID 24775436, compound

HRID 645758Notes

Reaction equation

HRID 645758 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20](Cl)=[O:21])[C:10]([C:23]3[CH:24]=[N:25][C:26]([O:32][CH2:33][CH3:34])=[CH:27][C:28]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:4][CH:3]=1.[N:35]1([CH2:41][CH2:42][OH:43])[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[C@@H:12]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[N:11]([C:20]([N:38]3[CH2:39][CH2:40][N:35]([CH2:41][CH2:42][OH:43])[CH2:36][CH2:37]3)=[O:21])[C:10]([C:23]3[CH:24]=[N:25][C:26]([O:32][CH2:33][CH3:34])=[CH:27][C:28]=3[O:29][CH2:30][CH3:31])=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 76771-(2-Hydroxyethyl)piperazineHCID 86613634HCID 86613634, compound

Product 1

HCID 24775436HCID 24775436, compound

Procedure

cis-4-[4,5-Bis-(4-chloro-phenyl)-2-(4,6-diethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 32) was reacted with 2-piperazine-1-yl-ethanol (Aldrich) to give cis-[4,5-bis-(4-chloro-phenyl)-2-(4,6-diethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-hydroxy-ethyl)-piperazin-1-yl]-methanone hydrochloride in an analogous manner as described in example 1.

Sources & evidence

ORD record
ord-7a22e17150a44750a82eba927f9aafa6
Source dataset
uspto-grants-2010_04
Patent number
US07705007B2

Reaction notes

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