2-(Piperazin-1-yl)acetamide hydrochloride → 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide

Participants

Role	Name	HCID	Charge
Reactant	2-(Piperazin-1-yl)acetamide hydrochloride	HCID 16294104	—
Reactant	cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613636	—
Product	2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide	HCID 24775526	—

Reaction Steps

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 34) was reacted with 2-piperazin-1-yl-acetamide hydrochloride (Matrix) to give 2-{4-[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetamide in an analogous manner as described in example 1. LR-MS: 586.2 [(M+H)+]

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705007B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-7156e496ea344bd390caa728a49df7b6
Source note	uspto-grants-2010_04