1-(2-Methanesulfonylethyl)piperazine dihydrochloride → [(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone

Participants

Role	Name	HCID	Charge
Reactant	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
Reactant	cis-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613636	—
Product	[(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone	HCID 24775709	—

Reaction Steps

2-{4-[(4S,5R)-4,5-Bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with 1-(2-methanesulfonylethyl)piperazine dihydrochloride (example 3) to give [(4S,5R)-4,5-bis-(4-chloro-phenyl)-2-(3-ethoxy-thiophen-2-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. LR-MS: 635.1 [(M+H)+].

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07705007B2
Source dataset	uspto-grants-2010_04
ORD ID	ord-79a1730424df41e487316ad482d376ce
Source note	uspto-grants-2010_04