HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 64580Generated: October 29, 2026
Sodium hydride → HCID 13670536, compound
https://huagongshe.com/reaction/64580
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 2-Chloroquinoxaline | HCID 238938 | — |
| Reactant | 2-(4-hydroxyphenoxy)propanenitrile | HCID 10607087 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 13670536 | HCID 13670536 | — |
Reaction Steps
In a nitrogen atmosphere, add a solution of 4.9 g (0.03 mole) 2-(4-hydroxyphenoxy)propionitrile in 20 cc dimethylformamide to 1.5 g sodium hydride (0.03 mole) in 20 cc dimethylformamide. When the evolution of hydrogen ceases, add 4.9 g (0.03 mole) 2-chloroquinoxaline. Heat at approximately 130° C. until the reaction is complete. Pour into water and extract the product in ether. Dry the ethereal extracts and concentrate to yield the desired nitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04609396 |
|---|
| Source dataset | uspto-grants-1986_09 |
|---|
| ORD ID | ord-cf3057c5907343aeb16919d522630d49 |
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| Source note | uspto-grants-1986_09 |
|---|
