3-cyclobutyl-7-(piperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine → HCID 178520981, compound

HRID 645909Notes

Reaction equation

HRID 645909 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][C:9]3[CH:12]=[C:13]([O:16][CH:17]4CCNCC4)[CH:14]=[CH:15][C:8]=3[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[N:23]1([C:29]([C@@H:31]2[CH2:36][CH2:35][C@H](O)[CH2:33][CH2:32]2)=[O:30])[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1>>[CH:1]1([N:5]2[CH2:6][CH2:7][C:8]3[CH:15]=[CH:14][C:13]([O:16][C@H:17]4[CH2:35][CH2:36][C@H:31]([C:29]([N:23]5[CH2:24][CH2:25][O:26][CH2:27][CH2:28]5)=[O:30])[CH2:32][CH2:33]4)=[CH:12][C:9]=3[CH2:10][CH2:11]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 685061053-cyclobutyl-7-(piperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepineHCID 178520992HCID 178520992, compound

Product 1

HCID 178520981HCID 178520981, compound

Procedure

Example 287 (E287) was prepared from 3-cyclobutyl-7-(piperidin-4-yloxy)-2,3,4,5-tetrahydro-1H-benzo[d]azepine (E6) and cis-4-(4-morpholinylcarbonyl)-cyclohexanol (D55) using the method described for Example 5a (E5a); MS (ES+) m/e 413 [M+H]+.

Sources & evidence

ORD record
ord-a45c20ea5ac3427bb29de94394a84c7b
Source dataset
uspto-grants-2010_04
Patent number
US07704994B2

Reaction notes

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