Tetrahydrofuran → HCID 11999707, compound

Participants

Reaction Steps

To a solution of 6 (0.20 g, 0.43 mmol) in dry THF (3 mL) at 0° C., NaH (60%, 0.021 g, 0.86 mmol) was added. After the mixture was stirred for 30 min, Mel (54 μL, 0.86 mmol) was added and stirring was continued overnight at room temperature. The reaction was quenched by the addition of saturated aqueous NH4Cl (0.5 mL). Solvent was evaporated under reduced pressure and the residue was extracted with CH2Cl2 (2×10 mL). The combined organic layer was washed with H20 (3 mL), brine (3 mL) and then dried over anhydrous Na2SO4. Solvent was evaporated under reduced pressure and the residual red syrup was purified by column chromatography using 35% acetone/hexane as the eluent to provide 7 (0.16 g, 75%) as a light yellow syrup.

Provenance & Evidence