HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Ethyl 1,2,3,4-tetrahydro-4-(2-(p-methoxybenzylthio)-5-nitrophenyl)-6-methyl-2-oxo-5-pyrimidine carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | HCID 13567319 | HCID 13567319 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl 1,2,3,4-tetrahydro-4-(2-(p-methoxybenzylthio)-5-nitrophenyl)-6-methyl-2-oxo-5-pyrimidine carboxylate | HCID 20236391 | — |
Reaction Steps
A mxiture of 5-nitro-2-(p-methoxybenzylthio)benzaldehyde (1.0 mmol), urea (1.5 mmol) and ethyl acetoacetate (1.5 mmol) in ethanol (2 ml) is heated with a catalytic amount of hydrochloric acid to yield the compound 2a.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04609494 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-a62a69bf50ea43c2a2ccbb9a1b6318da |
| Source note | uspto-grants-1986_09 |