Acetic Anhydride → Ethyl 3-acetyl-1,2,3,4-tetrahydro-4-(2-(p-methoxybenzylthio)-5-nitrophenyl)-6-methyl-2-oxo-5-pyrimidine carboxylate
Reaction equation
[CH3:1][O:2][C:3]1[CH:32]=[CH:31][C:6]([CH2:7][S:8][C:9]2[CH:14]=[CH:13][C:12]([N+:15]([O-:17])=[O:16])=[CH:11][C:10]=2[CH:18]2[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:22]([CH3:29])[NH:21][C:20](=[O:30])[NH:19]2)=[CH:5][CH:4]=1.[C:33](OC(=O)C)(=[O:35])[CH3:34]>>[C:33]([N:19]1[CH:18]([C:10]2[CH:11]=[C:12]([N+:15]([O-:17])=[O:16])[CH:13]=[CH:14][C:9]=2[S:8][CH2:7][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:32][CH:31]=2)[C:23]([C:24]([O:26][CH2:27][CH3:28])=[O:25])=[C:22]([CH3:29])[NH:21][C:20]1=[O:30])(=[O:35])[CH3:34]Participants
3
Procedure
The compound 2a is treated with excess acetic anhydride and is heated to reflux for 2 hours to yield the compound 2b.
Workup
- temperatureis heated
- temperatureto reflux for 2 hours
Sources & evidence
- ORD record
- ord-fb61ba9908244b769fbdca44ae13b607
- Source dataset
- uspto-grants-1986_09
- Patent number
- US04609494
Reaction notes
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