HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-acetyl-1,2,3,4-tetrahydro-4-(2-(p-methoxybenzylthio)-5-nitrophenyl)-6-methyl-2-oxo-5-pyrimidine carboxylate → Ethyl 5-acetyl-3,4,5,6-tetrahydro-2-methyl-8-nitro-4-oxo-2,6-methano-2H-1,3,5-benzothiadiazocine-11-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-acetyl-1,2,3,4-tetrahydro-4-(2-(p-methoxybenzylthio)-5-nitrophenyl)-6-methyl-2-oxo-5-pyrimidine carboxylate | HCID 20236389 | — |
| Reactant | Anisole trifluoroacetic acid | HCID 66633105 | — |
| Product | Ethyl 5-acetyl-3,4,5,6-tetrahydro-2-methyl-8-nitro-4-oxo-2,6-methano-2H-1,3,5-benzothiadiazocine-11-carboxylate | HCID 20236387 | — |
Reaction Steps
The compound 2b is treated with anhydrous trifluoroacetic acid:anisole (1:1) at 25° C. for 1 hour to yield a mixture of the diastereomers of the desired product. The individual diastereomers may be separated by chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04609494 |
| Source dataset | uspto-grants-1986_09 |
| ORD ID | ord-9e093d8c22bc41a8ac9f53cb929ef0ae |
| Source note | uspto-grants-1986_09 |