HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 18449044, compound → 4-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 18449044 | HCID 18449044 | — |
| Catalyst | Manganese dioxide | HCID 14801 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(5-Difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde | HCID 18449042 | 95.3% |
Reaction Steps
A solution of [4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-phenyl]-methanol (380 mg, 1.2 mmol) in DCM (20 mL) was treated with excess amount of MnO2 was stirred at room temperature for 24 hours. The mixture was filtered and the filtrate was concentrated under reduced pressure. Purification by chromatography (SiO2, 6:1 hexane/EtOAc) gave 4-(5-difluoromethoxy-3-trifluoromethyl-pyrazol-1-yl)-benzaldehyde (350 mg, 93% yield) as a syrup.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705029B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-9ae11630f6454ecda731d98dd5ccfd55 |
| Source note | uspto-grants-2010_04 |