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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646060Generated: October 25, 2026

Benzaldehyde → 2-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enone

https://huagongshe.com/reaction/646060

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzaldehydeHCID 240—
Reactant3,5-DimethylindoleHCID 98615—
Reactant2-Methyl-2-phenyl-cyclobutane-1,3-dioneHCID 68581027—
Product2-[(3,5-Dimethyl-1H-indol-2-yl)-phenyl-methyl]-3-hydroxy-4-methyl-4-phenyl-cyclobut-2-enoneHCID 25050879—

Reaction Steps

Using general procedure C, 2-methyl-2-phenyl-cyclobutane-1,3-dione (Lit. 1) was reacted with benzaldehyde and 3,5-dimethyl-1H-indole (Lit. 3) to give the title compound as a colorless solid. MS: 406.5 ([M−H]−).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705034B2
Source datasetuspto-grants-2010_04
ORD IDord-2aedb6d4798f470892b895736560a396
Source noteuspto-grants-2010_04