反应详情

To a mixture of 6-methyl-1H-indole-3-carbaldehyde oxime (0.66 g) and NiCl2.6H2O (0.97 g) in methanol (60 ml) was added at 22° C. sodium borohydride (3.04 g) in portions. The suspension was filtered and the filtrate evaporated. The residue was partitioned between aqueous NH3 (1%) and ethyl acetate, the organic layer was dried and evaporated to the give crude C-(6-methyl-1H-indol-3-yl)-methylamine as a yellow semi solid (0.68 g).

1. filtrationThe suspension was filtered
2. customthe filtrate evaporated
3. customThe residue was partitioned between aqueous NH3 (1%) and ethyl acetate
4. customthe organic layer was dried
5. customevaporated to the