HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → N-{2-[(2-hydroxy-3-methyl-4-oxo-3-phenyl-cyclobut-1-enyl)-phenyl-methyl]-6-methyl-1H-indol-3-ylmethyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | N-(6-Methyl-1H-indol-3-ylmethyl)-acetamide | HCID 68580773 | — |
| Reactant | 2-Methyl-2-phenyl-cyclobutane-1,3-dione | HCID 68581027 | — |
| Product | N-{2-[(2-hydroxy-3-methyl-4-oxo-3-phenyl-cyclobut-1-enyl)-phenyl-methyl]-6-methyl-1H-indol-3-ylmethyl}-acetamide | HCID 25050704 | — |
Reaction Steps
Using general procedure C, 2-methyl-2-phenyl-cyclobutane-1,3-dione (Lit. 1) was reacted with benzaldehyde and N-(6-methyl-1H-indol-3-ylmethyl)-acetamide to give N-{2-[(2-hydroxy-3-methyl-4-oxo-3-phenyl-cyclobut-1-enyl)-phenyl-methyl]-6-methyl-1H-indol-3-ylmethyl}-acetamide as a pale red solid. MS: 463.4 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705034B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-777026438ad744278570d99af1002a29 |
| Source note | uspto-grants-2010_04 |