HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → N-{2-[(2-Hydroxy-3-methyl-4-oxo-3-p-tolyl-cyclobut-1-enyl)-phenyl-methyl]-1H-indol-3-ylmethyl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | N-((1H-indol-3-yl)methyl)acetamide | HCID 12932197 | — |
| Reactant | 2-Methyl-2-p-tolyl-cyclobutane-1,3-dione | HCID 68581955 | — |
| Product | N-{2-[(2-Hydroxy-3-methyl-4-oxo-3-p-tolyl-cyclobut-1-enyl)-phenyl-methyl]-1H-indol-3-ylmethyl}-acetamide | HCID 59264915 | — |
Reaction Steps
Using general procedure C, 2-methyl-2-p-tolyl-cyclobutane-1,3-dione (from Example 4.1) was reacted with benzaldehyde and N-(1H-indol-3-ylmethyl)-acetamide (Lit. 6) to give the title compound as an off-white solid. MS: 463.4 ([M−H]−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07705034B2 |
| Source dataset | uspto-grants-2010_04 |
| ORD ID | ord-5efaf043d70d4a05bb95625aedb7ebd5 |
| Source note | uspto-grants-2010_04 |