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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 646074Generated: October 30, 2026

Benzaldehyde → N-{2-[(2-Hydroxy-3-methyl-4-oxo-3-p-tolyl-cyclobut-1-enyl)-phenyl-methyl]-6-methyl-1H-indol-3-ylmethyl}-acetamide

https://huagongshe.com/reaction/646074

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzaldehydeHCID 240—
ReactantN-(6-Methyl-1H-indol-3-ylmethyl)-acetamideHCID 68580773—
Reactant2-Methyl-2-p-tolyl-cyclobutane-1,3-dioneHCID 68581955—
ProductN-{2-[(2-Hydroxy-3-methyl-4-oxo-3-p-tolyl-cyclobut-1-enyl)-phenyl-methyl]-6-methyl-1H-indol-3-ylmethyl}-acetamideHCID 25050875—

Reaction Steps

Using general procedure C, 2-methyl-2-p-tolyl-cyclobutane-1,3-dione (from Example 4.1) was reacted with benzaldehyde and N-(6-methyl-1H-indol-3-ylmethyl)-acetamide (from Example 10.3) to give the title compound as a pale red solid. MS: 477.3 ([M−H]−).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07705034B2
Source datasetuspto-grants-2010_04
ORD IDord-43df1c27ffe145709e8daed30dfeedf9
Source noteuspto-grants-2010_04