1-Bromo-4-(propan-2-yloxy)benzene → 1,6-Bis(4-isopropoxyphenyl)-indole-2-carboxylic acid
Reaction equation
C([O:3][C:4]([C:6]1[NH:7][C:8]2[C:13]([CH:14]=1)=[CH:12][CH:11]=[C:10](Br)[CH:9]=2)=[O:5])C.[CH:16]([O:19][C:20]1[CH:25]=[CH:24][C:23](B(O)O)=[CH:22][CH:21]=1)([CH3:18])[CH3:17].Br[C:30]1[CH:35]=[CH:34][C:33]([O:36][CH:37]([CH3:39])[CH3:38])=[CH:32][CH:31]=1>>[CH:16]([O:19][C:20]1[CH:25]=[CH:24][C:23]([N:7]2[C:8]3[C:13](=[CH:12][CH:11]=[C:10]([C:30]4[CH:35]=[CH:34][C:33]([O:36][CH:37]([CH3:39])[CH3:38])=[CH:32][CH:31]=4)[CH:9]=3)[CH:14]=[C:6]2[C:4]([OH:3])=[O:5])=[CH:22][CH:21]=1)([CH3:18])[CH3:17]Participants
4
Procedure
The title compound was prepared in accordance with Example 1, using 6-bromoindole-2-carboxylic acid ethyl ester, 4-isopropoxyphenylboronic acid and 4-bromo-1-isopropoxybenzene.
Sources & evidence
- ORD record
- ord-08becddb165945e294a264e580042bf1
- Source dataset
- uspto-grants-2010_04
- Patent number
- US07705023B2
Reaction notes
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